Top Ten Agap2 - 100dichterinnen

A and B, FOXP1 expression level at protein and RNA level by Western blotting and qPCR, respectively, when HTR‐8/SVneo cells were transfected with FOXP1‐specific siRNAs. The AGAP2‐AS1 expression level was tested by qPCR after treated with siRNAs against AGAP2‐AS1 (B, right panels). AGAP2-AS1 is upregulated in lung cancer and can interact with EZH2 and LSD1 to suppress the expression of LATS2 and KLF2, thereby promoting tumor growth. 11 In gastric cancer, SP1 activates AGAP2-AS1 to increase cancer cell migration and proliferation.

To investigate lncRNA expression levels in NSCLC tissues compared with normal tissues, we first analyzed the 2017-02-16 · AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Furthermore, knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. AGAP2-AS1 has 521 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets. Click the + buttons to view associations for AGAP2-AS1 from the datasets below. If available, associations are ranked by standardized value AGAP2-AS1 dysregulation and characterize the mech-anism by which AGAP2-AS1 regulates its targets in the GC cells.

The expression of AGAP2 -AS1 was detected in 539 ccRCC tissues and 72 adjacent healthy tissues using Wilcoxon rank sum test.

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GeneCards - The Human Gene Compendium AGAP2-AS1 promoted glioma cell proliferation by sponging miR-15a/b-5p to upregulate the expression of HDGF; AGAP2-AS1 was upregulated and transcriptionally induced by SP1 in breast cancer..ChIP assays showed that AGAP2-AS1-bound CBP increased the enrichment of H3K27ac at the promoter region of MyD88, thus resulting in the upregulation of MyD88. Complete information for AGAP2-AS1 gene (RNA Gene), AGAP2 Antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers.

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Abstract Background Long noncoding RNAs (lncRNAs) have emerged as important regulators of tumorigenesis and cancer progression.

Mechanistically, AGAP2-AS1 is associated with HuR, and the AGAP2-AS1–HuR complex could directly bind to the CPT1, increasing its expression via improving RNA stability. In addition, AGAP2-AS1 AGAP2-AS1 has 521 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets. Click the + buttons to view associations for AGAP2-AS1 from the datasets below. If available, associations are ranked by standardized value The lncRNA AGAP2-AS1 is located on a cytogenetic band in chromosome 12q14.1, which contains 1567 nucleotides (12q14.1 is the gene symbol of AGAP2-AS1 in HUGO Gene Nomenclature Committee 48633, entrez gene: 100130776, Ensemble: ENSG00000255737). Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers.
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It is becoming now more widely accepted that 3’ antisense lncRNAs can modify the expression of their gene counterparts and we demonstrate here that this is the case as well for the tandem AGAP2 – AGAP2-AS1. 2021-02-18 2021-02-01 AGAP2-AS1 leads to a decrease in cell proliferation and migration, along with the repression of invasion and tumorigenesis.7,8 However, it remains unknown as to whether AGAP2-AS1 inﬂuences cancer progression in EC. Additionally, microRNAs (miRNAs), endogenous non-protein-cod- AGAP2-AS1 dysregulation and characterize the mech-anism by which AGAP2-AS1 regulates its targets in the GC cells. Taken together, the obtained findings may provide new insights into the critical role of the lncRNA AGAP2-AS1 in human GC tumorigenesis and progression.

Mechanistically, AGAP2-AS1 can repress LATS2 and KLF2 transcription via binding with EZH2 and LSD1 . AGAP2-AS1 was upregulated in MSC-cultured cells, and knockdown of AGAP2-AS1 reversed the MSC-mediated trastuzumab resistance.
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Gene ID Unique ID sequence Library number Human

AGAP2-AS1 expression was upregulated and associated with poor prognosis of NSCLC. To investigate lncRNA expression levels in NSCLC tissues compared with normal tissues, we first analyzed the 2017-02-16 · AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Furthermore, knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. AGAP2-AS1 has 521 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

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OncoPredictor Genomics Data - PLOS

(A) KRAS, FGFR4, and CTSK were significantly upregulated in SKOV3.ip and OVCAR3 cells after AGAP2-AS1 silencing, which was consistent with the PCR array results. AGAP2-AS1 is upregulated in lung cancer and can interact with EZH2 and LSD1 to suppress the expression of LATS2 and KLF2, thereby promoting tumor growth. 11 In gastric cancer, SP1 activates AGAP2-AS1 to increase cancer cell migration and proliferation. 12 In breast cancer, overexpression of AGAP2-AS1 regulates the methylation of MyD88 to promote the development of chemoresistance. 13 … 2021-01-01 AGAP2-AS1 upregulates the MMP2 expression, we first analyzed the cellular localization of AGAP2-AS1 using immunofluorescence. As shown in Figure 3A, AGAP2-AS1 was localized mainly in the cytoplasm in TPC1 and K1 cells.

chr1 941791 942135 942082 Y HES4 NOC2L,KLHL17,PLEKHN1

Therefore, AGAP2-AS1 may serve as a novel biomarker for prognosis and act as a therapeutic target for the trastuzumab treatment. 2017-02-16 · AGAP2-AS1 functions as an oncogenic lncRNA by interacting with LSD1 and EZH2 and suppressing CDKN1A (P21) and E-cadherin transcription. CONCLUSIONS: Taken together, these findings imply that AGAP2-AS1 upregulated by SP1 plays an important role in GC development and progression by suppressing P21 and E-cadherin, which suggests that AGAP2-AS1 is a potential diagnostic marker and therapeutic 2019-05-14 · AGAP2-AS1-suppressive HCCLM3 cells that were transfected with anti-miR-16-5p were subjected to qRT-PCR for miR-16-5p. miR-16-5p restoration abrogated the effects of AGAP2-AS1 overexpression on cell proliferation (h), migration (i), invasion (j), EMT process (l) and apoptosis (k) of Hep3B cells. miR-16-5p knockdown reversed the suppressive effects of AGAP2-AS1 knockdown in HCCLM3 cells (h-l). AGAP2-AS1 can increase NSCLC cell proliferation, migration and invasion, but inhibit NSCLC cell apoptosis.

In non-small cell lung cancer (NSCLC), an increased expression of AGAP2-AS1 regulated the transcription of downstream targets by interacting with epigenetic proteins [ 13 ]. Besides, lncRNA AGAP2-AS1 could bind to miR-195-5p which targeted PDLIM5 and subsequently downregulated its expression, ultimately impeding the progression of prostate cancer. Additionally, lncRNA AGAP2-AS1 inhibition led to an up-regulated expression of miR-195-5p and down-regulated PDLIM5 expression, resulting in delayed tumor growth in vivo. Mechanistically, AGAP2-AS1 is associated with HuR, and the AGAP2-AS1–HuR complex could directly bind to the CPT1, increasing its expression via improving RNA stability. In addition, AGAP2-AS1 AGAP2-AS1 has 521 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets. Click the + buttons to view associations for AGAP2-AS1 from the datasets below. If available, associations are ranked by standardized value The lncRNA AGAP2-AS1 is located on a cytogenetic band in chromosome 12q14.1, which contains 1567 nucleotides (12q14.1 is the gene symbol of AGAP2-AS1 in HUGO Gene Nomenclature Committee 48633, entrez gene: 100130776, Ensemble: ENSG00000255737).